Biogen and Ionis Pharmaceuticals acknowledge support from the following organizations for SPINRAZA: Cure SMA, Muscular Dystrophy Association, and SMA Foundation, intellectual property licensed from Cold Spring Harbor Laboratory and the University of Massachusetts Medical School. For additional information about SPINRAZA (nusinersen), please visit www.spinraza.com . THE SPINRAZA PHASE 3 REGISTRATIONAL STUDY, ENDEAR ENDEAR was a randomized, double-blind, sham-controlled study in patients with infantile-onset (most likely to develop Type 1) SMA. http://www.blueridgefilmfest.com/logandixonnetwork/2016/12/09/news-on-painless-solutions-for-career-for-respiratory-medicineAt a planned interim analysis of ENDEAR, a greater percentage of infants treated with SPINRAZA achieved a motor milestone response compared to those who did not receive treatment (40% versus 0%; p<0.0001) as measured by the Hammersmith Infant Neurological Examination (HINE). Additionally, a smaller percentage of patients on SPINRAZA died (23%) compared to untreated patients (43%). Data from the other efficacy endpoints analyzed were consistently in favor of infants who received treatment. ABOUT IONIS PHARMACEUTICALS, INC. Ionis is the leading company in RNA-targeted drug discovery and development focused on developing drugs for patients who have the highest unmet medical needs, such as those patients with severe and rare diseases. Using its proprietary antisense technology, Ionis has created a large pipeline of first-in-class or best-in-class drugs, with over a dozen drugs in mid- to late-stage development. Drugs currently in Phase 3 development include volanesorsen, a drug Ionis is developing and plans to commercialize through its wholly owned subsidiary, Akcea Therapeutics, to treat patients with either familial chylomicronemia syndrome or familial partial lipodystrophy; and IONIS-TTRRx, a drug Ionis is developing with GSK to treat patients with all forms of TTR amyloidosis. SPINRAZA (nusinersen) is a drug that has been approved in the U.S. for the treatment of spinal muscular atrophy (SMA) in pediatric and adult patients.
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(Spain) has agreed to purchase approximately 88% of the aggregate amount of the AT1 Notes. The offering of the AT1 Notes was registered with the U.S. Securities and Exchange Commission (“SEC”) and the Company expects that the AT1 Notes will be registered in the Mexican National Securities Registry (Registro Nacional de Valores)of theMexican National Banking and Securities Commission(Comision Nacional Bancaria y de Valores). Santander Investment Securities Inc., Goldman, Sachs & Co. and Morgan Stanley & Co. LLC are joint book-running managers for the offering. The offering is being made pursuant to an effective shelf registration statement filed with the SEC on December 21, 2016. The offering of the AT1 Notes may be made only by means of a prospectus supplement and the accompanying prospectus, copies of which, when available may be obtained by contacting Santander Investment Securities Inc. at 45 East 53rd Street, New York, New York 10022 (tel: +1-855-403-3636), to Goldman Sachs & Co. at 200 West Street, New York, New York 10282 (tel: +1-866-471-2526), or to Morgan Stanley & Co. LLC at 1585 Broadway, New York, New York 10036 (tel: +1-866-718-1649).
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